AMPK negatively regulates tensin-dependent integrin activity

Abstract

Tight regulation of integrin activity is paramount for dynamic cellular functions such as cell matrix adhesion and mechanotransduction. Integrin activation is achieved through intracellular interactions at the integrin cytoplasmic tails and through integrin-ligand binding. In this study, we identify the metabolic sensor AMP-activated protein kinase (AMPK… (More)
DOI: 10.1083/jcb.201609066

5 Figures and Tables

Topics

  • Presentations referencing similar topics