AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.

Abstract

BACKGROUND AND PURPOSE Blocking of the autophagy-signaling has the potential to improve cancer therapy. In the present study, the role of autophagy for radioresistance of human tumor cells was tested under clinically relevant hypoxia (1% O2). MATERIALS AND METHODS Non-small cell lung cancer cell lines A549 and H460, head and neck squamous cell carcinoma… (More)
DOI: 10.1016/j.radonc.2015.08.012

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@article{Chaachouay2015AMPKindependentAP, title={AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.}, author={Hassan Chaachouay and Birgit Fehrenbacher and Mahmoud Toulany and Martin Alexander Schaller and Gabriele Multhoff and Hans Peter Rodemann}, journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology}, year={2015}, volume={116 3}, pages={409-16} }