AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol.


AMP-activated protein kinase (AMPK) enhances glucose transporter GLUT4 regulation. AMPK also suppresses energy-consuming pathways such as cholesterol synthesis. Interestingly, recent in vitro and in vivo data suggest that excess membrane cholesterol impairs GLUT4 regulation. Therefore, this study tested whether a beneficial, GLUT4-regulatory aspect of AMPK… (More)
DOI: 10.1210/en.2011-2099


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