AMPK couples p73 with p53 in cell fate decision

  title={AMPK couples p73 with p53 in cell fate decision},
  author={Yaarit Adamovich and Julia Adler and V Meltser and Nina Reuven and Yosef Shaul},
  journal={Cell Death and Differentiation},
The p53 family of proteins has an important role in determining cell fate in response to different types of stress, such as DNA damage, hypoxia, or oncogenic stress. In recent years, p53 has also been shown to respond to metabolic stress, and to be induced by the AMP-activated protein kinase (AMPK), a central cellular energy sensor. A bioinformatic analysis revealed three putative AMPK phopshorylation sites in p73, a p53 tumor suppressor paralog. In vitro and in vivo assays confirmed that AMPK… CONTINUE READING
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