AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance.

@article{Dzamko2010AMPKBD,
  title={AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance.},
  author={Nicolas L Dzamko and Bryce J. W. van Denderen and Andrea L. Hevener and Sebastian Beck J\orgensen and Jane E. Honeyman and Sandra Galic and Z P Chen and Matthew J Watt and Duncan J. Campbell and Gregory R Steinberg and Bruce E. Kemp},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 1},
  pages={115-22}
}
The AMP-activated protein kinase (AMPK) is an alphabetagamma heterotrimer that regulates appetite and fuel metabolism. We have generated AMPK beta1(-/-) mice on a C57Bl/6 background that are viable, fertile, survived greater than 2 years, and display no visible brain developmental defects. These mice have a 90% reduction in hepatic AMPK activity due to loss… CONTINUE READING