AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.

@article{Kuznetsov2011AMPKAA,
  title={AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.},
  author={Jeffim N. Kuznetsov and Guy J. Leclerc and Gilles M. Leclerc and Julio C Barredo},
  journal={Molecular cancer therapeutics},
  year={2011},
  volume={10 3},
  pages={
          437-47
        }
}
AICAr is a cell-permeable nucleotide that has been used in vivo and in vitro to activate AMPK. Our previous findings have shown that AICAr as a single agent induces dose- and time-dependent growth inhibition in acute lymphoblastic leukemia (ALL) cell lines. In addition, the combination of AICAr with antifolates [methotrexate (MTX) or pemetrexed] has been shown to further potentiate AMPK activation and to lead to greater cytotoxicity and growth inhibition in leukemia and other malignant cell… CONTINUE READING

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