AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

@inproceedings{Herms2015AMPKAP,
  title={AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation},
  author={Albert Herms and Marta Bosch and Babu J. N. Reddy and Nicole L Schieber and Alba Fajardo and Celia Rup{\'e}rez and Andrea Fern{\'a}ndez-Vidal and Charles Ferguson and Carles Rentero and Francesc Tebar and Carlos Enrich and Robert G. Parton and Steven P. Gross and Albert Pol},
  booktitle={Nature communications},
  year={2015}
}
Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with other organelles are unclear. Here we show that during nutrient starvation, LDs and mitochondria relocate on detyrosinated MT from the cell centre to adopt a dispersed distribution. In the cell… CONTINUE READING