AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training.

@article{LeeYoung2009AMPKAI,
  title={AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training.},
  author={Robert S. Lee-Young and Benedict J. Canny and Damian E. Myers and Glenn Kevin McConell},
  journal={Journal of applied physiology},
  year={2009},
  volume={107 1},
  pages={283-9}
}
AMP-activated protein kinase (AMPK) has been extensively studied in whole muscle biopsy samples of humans, yet the fiber type-specific expression and/or activation of AMPK is unknown. We examined basal and exercise AMPK-alpha Thr(172) phosphorylation and AMPK subunit expression (alpha(1), alpha(2), and gamma(3)) in type I, IIa, and IIx fibers of human skeletal muscle before and after 10 days of exercise training. Before training basal AMPK phosphorylation was greatest in type IIa fibers (P < 0… CONTINUE READING
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