AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1.

@article{Treins2006AMPKAI,
  title={AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1.},
  author={Caroline Treins and Joseph Murdaca and E Van Obberghen and Sophie Giorgetti-Peraldi},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={342 4},
  pages={1197-202}
}
Insulin, insulin like growth factor (IGF)-1, and AMP-activated protein kinase (AMPK) signaling regulate independently angiogenesis through vascular endothelial growth factor (VEGF) expression. In the present study, we investigated a potential cross-talk between these signaling pathways on hypoxia-inducible factor (HIF)-1alpha and VEGF expression. Retinal epithelial ARPE-19 cells were treated with AICAR, an AMPK activator, alone or in combination with insulin and IGF-1. AICAR stimulated VEGF… CONTINUE READING

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