AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway.

@article{Meng2011AMPKAE,
  title={AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway.},
  author={Rongsen Meng and Zhaohui Pei and Aixia Zhang and Yutian Zhou and Xingming Cai and Baolin Chen and Guanjie Liu and Weiyi Mai and Jianrui Wei and Yugang Dong},
  journal={Archives of biochemistry and biophysics},
  year={2011},
  volume={511 1-2},
  pages={1-7}
}
Activation of adenosine monophosphate-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy through peroxisome proliferators-activated receptor-α (PPARα) signaling pathway, but the detailed mechanism remains unclear. A rat model of cardiac hypertrophy created by transaortic constriction (TAC) was used to investigate the mechanism involved in regulation of PPARα activity by AMPK. It was observed that treatment with AICAR (5-aminoimidazole 1 carboxamide ribonucleoside), an… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2018

AMPK and cardiac remodelling

Science China Life Sciences • 2017

Similar Papers

Loading similar papers…