AMPK activation by long chain fatty acyl analogs.

  title={AMPK activation by long chain fatty acyl analogs.},
  author={Ghadeer Za'tara and Jacob Bar-Tana and Bella Kalderon and Marianne Suter and Etedal Morad and Dmitry Samovski and Dietbert Neumann and Rachel Hertz},
  journal={Biochemical pharmacology},
  volume={76 10},
The antidiabetic efficacy of first-line insulin sensitizers (e.g., metformin, glitazones) is accounted for by activation of AMP-activated protein kinase (AMPK). Long chain fatty acids (LCFA) activate AMPK, but their putative antidiabetic efficacy is masked by their beta-oxidized or esterified lipid products. Substituted alpha,omega-dicarboxylic acids of 14-18 carbon atoms in length (MEDICA analogs) are not metabolized beyond their acyl-CoA thioesters, and may therefore simulate AMPK activation… CONTINUE READING


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