AMPK activates LXRα and ABCA1 expression in human macrophages.

@article{Kemmerer2016AMPKAL,
  title={AMPK activates LXRα and ABCA1 expression in human macrophages.},
  author={Marina Kemmerer and Ilka Wittig and Florian M Richter and Bernhard Br{\"u}ne and Dmitry Namgaladze},
  journal={The international journal of biochemistry & cell biology},
  year={2016},
  volume={78},
  pages={1-9}
}
ATP-binding cassette transporter A1 (ABCA1) is a key modulator of macrophage cholesterol homeostasis. We studied the impact of AMP-activated protein kinase (AMPK) on ABCA1 expression in primary human and THP-1 macrophages. Pharmacological or genetic activation of AMPK increased mRNA and protein expression of ABCA1 and its transcriptional activator liver X… CONTINUE READING