AMPK Negatively Regulates Peripheral Myelination via Activation of c-Jun

  title={AMPK Negatively Regulates Peripheral Myelination via Activation of c-Jun},
  author={Xiaoyu Liu and Su Peng and Yahong Zhao and Tingting Zhao and Meihong Wang and Lan Luo and Yumin Yang and Cheng Sun},
  journal={Molecular Neurobiology},
The process of Schwann cells (SCs) forming a sheath around axons is termed as myelination, which plays a pivotal role for proper physiological function in the peripheral nervous system (PNS). The molecular mechanisms regulating SC myelination in the PNS remain to be elucidated. Here, we show that AMP-activated protein kinase (AMPK) in sciatic nerves was gradually decreased during the PNS myelination process. Pharmacological interventions showed that activation of AMPK by AICAR attenuated myelin… CONTINUE READING
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