AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization.

@article{Asby2015AMPKAV,
  title={AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization.},
  author={Daniel J Asby and Francesco Cuda and Maxime Beyaert and Franchesca Dawn Houghton and Felino Ramon A Cagampang and Ali Tavassoli},
  journal={Chemistry & biology},
  year={2015},
  volume={22 7},
  pages={838-48}
}
5-Aminoimidazole-4-carboxamide ribonucleotide (known as ZMP) is a metabolite produced in de novo purine biosynthesis and histidine biosynthesis, but only utilized in the cell by a homodimeric bifunctional enzyme (called ATIC) that catalyzes the last two steps of de novo purine biosynthesis. ZMP is known to act as an allosteric activator of the cellular energy sensor adenosine monophosphate-activated protein kinase (AMPK), when exogenously administered as the corresponding cell-permeable… CONTINUE READING
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