AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen

@article{Polekhina2003AMPKS,
  title={AMPK $\beta$ Subunit Targets Metabolic Stress Sensing to Glycogen},
  author={G. Polekhina and Abhilasha Gupta and B. Michell and B. Denderen and S. Murthy and S. Feil and I. Jennings and D. Campbell and L. Witters and M. Parker and B. Kemp and D. Stapleton},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={867-871}
}
Abstract AMP-activated protein kinase (AMPK) is a multisubstrate enzyme activated by increases in AMP during metabolic stress caused by exercise, hypoxia, lack of cell nutrients [1], as well as hormones, including adiponectin and leptin [2, 3]. Furthermore, metformin and rosiglitazone, frontline drugs used for the treatment of type II diabetes, activate AMPK [4]. Mammalian AMPK is an αβγ heterotrimer with multiple isoforms of each subunit comprising α1, α2, β1, β2, γ1, γ2, and γ3, which have… Expand

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