AMPK α2 subunit is involved in platelet signaling, clot retraction, and thrombus stability.

Abstract

The adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a regulator of energy balance at the cellular and whole-body levels, but little is known about the role of AMPK in platelet activation. We report that both the α1 and α2 AMPK isoforms are expressed by human and murine platelets and that thrombin elicits the phosphorylation of AMPKα as well… (More)
DOI: 10.1182/blood-2010-04-279612

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