AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells.

@article{Song2011AMPK2DE,
  title={AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells.},
  author={Ping Song and Shuangxi Wang and Chaoyong He and Shaobin Wang and Bin Liang and Benoit Viollet and Ming-Hui Zou},
  journal={Circulation research},
  year={2011},
  volume={109 11},
  pages={1230-9}
}
RATIONALE Adenosine monophosphate-activated protein kinase (AMPK), a metabolic and redox sensor, is reported to suppress cell proliferation of nonmalignant and tumor cells. Whether AMPKα alters vascular neointima formation induced by vascular injury is unknown. OBJECTIVE The aim of this study was to determine the roles of AMPKα in the development of vascular neointima hyperplasia and to elucidate the underlying mechanisms. METHODS AND RESULTS Vascular smooth muscle cell (VSMC) proliferation… CONTINUE READING