AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis.

  title={AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis.},
  author={Kathryn N. Phoenix and Charan V. Devarakonda and Melissa M. Fox and Laura E. Stevens and Kevin P. Claffey},
  journal={Genes & cancer},
  volume={3 1},
AMP-activated kinase (AMPK) is a key metabolic sensor and stress signaling kinase. AMPK activity is known to suppress anabolic processes such as protein and lipid biosynthesis and promote energy-producing pathways including fatty acid oxidation, resulting in increased cellular energy. In addition, AMPK localizes to centrosomes during cell division, plays a role in cellular polarization, and directly targets p53, affecting apoptosis. Two distinct catalytic AMPKα isoforms exist: α1 and α2… CONTINUE READING


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AMPKalpha modulation in cancer progression: multilayer integrative transcriptome analysis in Asian gastric cancer

  • YH Kim, H Liang, X Liu
  • Cancer Res
  • 2012
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