AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.

@article{Mounier2013AMPK1RM,
  title={AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.},
  author={R{\'e}mi Mounier and Marine Theret and Ludovic Arnold and Sylvain Cuvellier and Laurent Bultot and Olga G{\"o}ransson and Nieves Sanz and Arnaud Ferry and Kei Sakamoto and Marc Foretz and Benoit Viollet and B{\'e}n{\'e}dicte Chazaud},
  journal={Cell metabolism},
  year={2013},
  volume={18 2},
  pages={251-64}
}
Macrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence for a role of AMPKα1, a master regulator of energy homeostasis, in macrophage skewing that occurs during skeletal muscle regeneration. Muscle regeneration was impaired in AMPKα1(-/-) mice. In vivo loss-of-function (LysM-Cre;AMPKα1(fl/fl) mouse) and rescue (bone marrow transplantation) experiments showed that macrophagic AMPKα1… CONTINUE READING

From This Paper

Topics from this paper.
96 Citations
33 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 96 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

venom from Notechis scutatus scutatus

  • A. Woods, K. Dickerson, +5 authors D. Carling
  • Cell Metab
  • 2005
Highly Influential
5 Excerpts

Activated Protein Kinase Accentuates Lipopolysaccharide-Induced Lung Endothelial Barrier Dysfunction and Lung Injury in Vivo

  • C. O. Yi, B. T. Jeon, +8 authors G.J
  • Am J Pathol
  • 2011
Highly Influential
5 Excerpts

inflammation during tissue repair

  • A. Rivollier, J. He, A. Kole, V. Valatas, B. L. Kelsall
  • J. Cell Biol
  • 2012

Similar Papers

Loading similar papers…