AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.

@article{Mounier2013AMPK1RM,
  title={AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.},
  author={R. Mounier and M. Theret and Ludovic Arnold and S. Cuvellier and Laurent Bultot and O. G{\"o}ransson and Nieves Sanz and A. Ferry and K. Sakamoto and M. Foretz and B. Viollet and B. Chazaud},
  journal={Cell metabolism},
  year={2013},
  volume={18 2},
  pages={
          251-64
        }
}
  • R. Mounier, M. Theret, +9 authors B. Chazaud
  • Published 2013
  • Medicine, Biology
  • Cell metabolism
  • Macrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence for a role of AMPKα1, a master regulator of energy homeostasis, in macrophage skewing that occurs during skeletal muscle regeneration. Muscle regeneration was impaired in AMPKα1(-/-) mice. In vivo loss-of-function (LysM-Cre;AMPKα1(fl/fl) mouse) and rescue (bone marrow transplantation) experiments showed that macrophagic AMPKα1… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 60 REFERENCES
    A CREB-C/EBPβ cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair
    439
    Important role for AMPKαl in limiting skeletal muscle cell hypertrophy
    121
    AMP‐activated protein kinase enhances the phagocytic ability of macrophages and neutrophils
    98
    Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.
    762
    Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells
    87