AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

@article{Dandapani2013AMPKOT,
  title={AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?},
  author={Madhumita Dandapani and David Grahame Hardie},
  journal={Biochemical Society transactions},
  year={2013},
  volume={41 2},
  pages={687-93}
}
AMPK (AMP-activated protein kinase) is a sensor of cellular energy status that appears to have arisen during early eukaryotic evolution. In the unicellular eukaryote Saccharomyces cerevisiae, the AMPK orthologue is activated by glucose starvation and is required for the switch from glycolysis (fermentation) to oxidative metabolism when glucose runs low. In mammals, rapidly proliferating cells (including tumour cells) and immune cells involved in inflammation both tend to utilize rapid glucose… CONTINUE READING