AMPK, MAPK and Bax in the heart: some questions answered.

@article{Borutait2008AMPKMA,
  title={AMPK, MAPK and Bax in the heart: some questions answered.},
  author={Vilmantė Borutaitė},
  journal={The Biochemical journal},
  year={2008},
  volume={412 2},
  pages={e15-6}
}
The question of how Bax is activated during apoptosis to perform its role in permeabilization of mitochondrial membranes is intriguing for investigators in the wide field of cell death research. In their paper published in the Biochemical Journal in 2006, Capano and Crompton presented their discovery that simulated ischaemia causes rapid activation of AMPK (AMP-activated protein kinase) which phosphorylates and activates p38 MAPK (mitogen-activated protein kinase) leading to Bax activation and… CONTINUE READING
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