AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation

  title={AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation},
  author={Sa{\vs}a Peter and Bastiaan H A Urbanus and R. Klaassen and B. Wu and H. Boele and Sameha Azizi and J. Slotman and A. Houtsmuller and M. Schonewille and F. Hoebeek and S. Spijker and A. Smit and C. D. De Zeeuw},
  journal={Cell Reports},
  • Saša Peter, Bastiaan H A Urbanus, +10 authors C. D. De Zeeuw
  • Published 2020
  • Chemistry, Medicine
  • Cell Reports
  • Summary The majority of excitatory postsynaptic currents in the brain are gated through AMPA-type glutamate receptors, the kinetics and trafficking of which can be modulated by auxiliary proteins. It remains to be elucidated whether and how auxiliary proteins can modulate synaptic function to contribute to procedural memory formation. In this study, we report that the AMPA-type glutamate receptor (AMPAR) auxiliary protein SHISA6 (CKAMP52) is expressed in cerebellar Purkinje cells, where it co… CONTINUE READING
    4 Citations


    The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory
    • 33
    Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3
    • 49
    • Highly Influential
    • PDF
    Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity
    • 46
    • PDF
    CKAMP44: A Brain-Specific Protein Attenuating Short-Term Synaptic Plasticity in the Dentate Gyrus
    • 215
    Purkinje Cell-Specific Knockout of the Protein Phosphatase PP2B Impairs Potentiation and Cerebellar Motor Learning
    • 181
    • PDF
    Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins
    • 129
    • Highly Influential
    • PDF
    αCaMKII Is Essential for Cerebellar LTD and Motor Learning
    • 186
    • Highly Influential
    • PDF
    Synaptic plasticity through activation of GluA3-containing AMPA-receptors
    • 25
    • PDF
    Impairment of AMPA Receptor Function in Cerebellar Granule Cells of Ataxic Mutant Mouse Stargazer
    • 257
    • PDF
    CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus
    • 9
    • Highly Influential
    • PDF