AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation

@article{Peter2020AMPARAP,
  title={AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation},
  author={Sa{\vs}a Peter and Bastiaan H A Urbanus and R. Klaassen and B. Wu and H. Boele and Sameha Azizi and J. Slotman and A. Houtsmuller and M. Schonewille and F. Hoebeek and S. Spijker and A. Smit and C. D. De Zeeuw},
  journal={Cell Reports},
  year={2020},
  volume={31}
}
  • Saša Peter, Bastiaan H A Urbanus, +10 authors C. D. De Zeeuw
  • Published 2020
  • Chemistry, Medicine
  • Cell Reports
  • Summary The majority of excitatory postsynaptic currents in the brain are gated through AMPA-type glutamate receptors, the kinetics and trafficking of which can be modulated by auxiliary proteins. It remains to be elucidated whether and how auxiliary proteins can modulate synaptic function to contribute to procedural memory formation. In this study, we report that the AMPA-type glutamate receptor (AMPAR) auxiliary protein SHISA6 (CKAMP52) is expressed in cerebellar Purkinje cells, where it co… CONTINUE READING
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