AMPA receptor trafficking and learning.

  title={AMPA receptor trafficking and learning.},
  author={Joyce Keifer and Z Zheng},
  journal={The European journal of neuroscience},
  volume={32 2},
In the last few years it has become clear that AMPA-type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory, as well as disease states involving cognitive dysfunction. Here, we summarize the evidence for AMPAR trafficking as a mechanism underlying a variety of… CONTINUE READING

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