• DOI:10.1385/MN:32:2:145
• Corpus ID: 21618951

AMPA receptor subunit GluR2 gates injurious signals in ischemic stroke

@article{Soundarapandian2005AMPARS,
  title={AMPA receptor subunit GluR2 gates injurious signals in ischemic stroke},
  author={Mangala Meenakshi Soundarapandian and Wei Tu and Peter Hsien Li Peng and Antonis Zervos and You Ming Lu},
  journal={Molecular Neurobiology},
  year={2005},
  volume={32},
  pages={145-155}
}

• M. M. Soundarapandian, Wei Tu, +2 authors Y. Lu
• Published 29 September 2005
• Biology
• Molecular Neurobiology

Ischemic stroke, or a brain attack, is the third leading cause of death in developed countries. A critical feature of the disease is a highly selective pattern of neuronal loss; certain identifiable subsets of neurons—particularly CA1 pyramidal neurons in the hippocampus—are severely damaged, whereas others remain intact. A key step in this selective neuronal injury is Ca2+/Zn2+ entry into vulnerable neurons through α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor channels, a principle subtype of glutamate receptors. AMPA receptor channels are assembled from glutamate receptor (GluR)1, -2, -3, and -4 subunits. Circumstance data have indicated that the GluR2 subunits dictate Ca2+/Zn2+ permeability of AMPA receptor channels and gate injurious Ca2+/Zn2+ signals in vulnerable neurons. Therefore, targeting to the AMPA receptor subunit GluR2 can be considered a practical strategy for stroke therapy.