AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability

@inproceedings{Brechet2017AMPAreceptorSB,
  title={AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability},
  author={Aline Brechet and Rebecca Buchert and Jochen Schwenk and Sami Boudkkazi and Gerd Zolles and Karine Siquier-Pernet and Irene Schaber and Wolfgang Bildl and Abdelkrim Saadi and Christine B{\^o}le-Feysot and Patrick Linsel Nitschke and Andr{\'e} Reis and Heinrich Sticht and Nouriya A Al-Sanna'a and Arndt Rolfs and {\'A}kos Kulik and U. Schulte and Laurence Colleaux and Rami Abou Jamra and Bernd Fakler},
  booktitle={Nature communications},
  year={2017}
}
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neurotransmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the endoplasmic reticulum (ER) and lack the core-subunits typical for AMPARs in the plasma membrane. Central components of these ER AMPARs are the proteome constituents FRRS1l (C9orf4) and CPT1c that… CONTINUE READING