AMPA receptor involvement in 5-hydroxytryptamine2A receptor-mediated pre-frontal cortical excitatory synaptic currents and DOI-induced head shakes

@article{Zhang2008AMPARI,
  title={AMPA receptor involvement in 5-hydroxytryptamine2A receptor-mediated pre-frontal cortical excitatory synaptic currents and DOI-induced head shakes},
  author={Ce Zhang and G. Marek},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2008},
  volume={32},
  pages={62-71}
}
  • Ce Zhang, G. Marek
  • Published 2008
  • Chemistry, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Glutamate plays an important role in the psychotomimetic effects of both channel blocking N-methyl D-aspartate (NMDA) receptor antagonists and hallucinogenic drugs which activate 5-hydroxytryptamine2A (5-HT2A) receptors. Previous work suggested that activation of non-NMDA ionotropic glutamate receptors mediates the effects of 5-HT-induced excitatory post-synaptic potentials/currents (EPSPs/EPSCs) when recording from layer V pyramidal cells in the rat medial pre-frontal cortex (mPFC). However… Expand
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