AMPA receptor involvement in 5-hydroxytryptamine2A receptor-mediated pre-frontal cortical excitatory synaptic currents and DOI-induced head shakes

  title={AMPA receptor involvement in 5-hydroxytryptamine2A receptor-mediated pre-frontal cortical excitatory synaptic currents and DOI-induced head shakes},
  author={Ce Zhang* and Gerard J. Marek},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • Ce Zhang*G. Marek
  • Published 1 January 2008
  • Biology, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry

Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice

The robust attenuation of DOI-induced head twitches in the mGlu2 receptor KO mice appears to reflect the critical role of glutamate in ongoing regulation of 5-HT2A receptors in the prefrontal cortex.

Interactions of Hallucinogens with the Glutamatergic System: Permissive Network Effects Mediated Through Cortical Layer V Pyramidal Neurons.

  • G. Marek
  • Biology
    Current topics in behavioral neurosciences
  • 2018
The effects on 5-HT2A receptors and related GPCRs appear to play a major role in the behavioral effects of serotonergic hallucinogens, such as head twitches in rodents and higher order behaviors such as rodent lever pressing on the differential-reinforcement-of-low rate 72-s (DRL72-s) schedule.

Regulation of Cortical 5-Hydroxytryptamine 2A -Receptor Mediated Electrophysiological Responses in the Rat Following Daily Oral Lithium Administration

  • Psychology, Biology
  • 2016
While not having an effect on the concentration-response of 5-HT-induced EPSCs in the medial PFC, lithium did enhance both the onset and magnitude of desensitization for 5-hydroxytryptamine 2A (5-HT 2A) receptor trafficking lithium in the PFC.

D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT2A receptor agonist DOI

Orexin 2 Receptor Antagonists from Prefrontal Cortical Circuitry to Rodent Behavioral Screens

The treatment of mood disorders is an additional potential indica-tion for orexin receptor antagonists beyond simply improving sleep by suppressing hallucinogen-induced head twitches and producing antidepressant-like effects on the differential-reinforcement-of-low-rate 72-s (DRL72-s) schedule of reinforcement.

Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen

Chronic treatment with the mGlu2/3 agonist LY379268 would alter the behavioral response to a phenethylamine hallucinogen, 25CN-NBOH, which acts as a selective 5-HT2A agonist, and these data support the hypothesis that mGlam 2/3 receptors play a prominent role in modulating the behavior response to 5- HT2A receptor activation.

Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice



Group III Metabotropic Glutamate Receptor Agonists Selectively Suppress Excitatory Synaptic Currents in the Rat Prefrontal Cortex Induced by 5-Hydroxytryptamine2A Receptor Activation

It is found that the group III mGlu receptor agonists appear to have relatively minimal effects on glutamate released by sources other than thalamocortical afferents, and activation of both mGLU4 andmGlu8 receptors may play a role in suppressing 5-HT-induced EPSCs.

The Role of Kv1.2-Containing Potassium Channels in Serotonin-Induced Glutamate Release from Thalamocortical Terminals in Rat Frontal Cortex

Results indicate that blockade of Kv1.2-containing potassium channels is part of the mechanism underlying 5-HT-induced glutamate release from thalamocortical terminals, suggesting a common mechanism of action.

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

A close coupling between mGlu2/3 and 5-HT(2A) receptors in the prefrontal cortex that may be relevant for novel therapeutic approaches in the treatment of neuropsychiatric syndromes such as depression and schizophrenia is suggested.

Clozapine and Haloperidol Differently Suppress the MK-801-Increased Glutamatergic and Serotonergic Transmission in the Medial Prefrontal Cortex of the Rat

The local effects of clozapine and haloperidol paralleled those observed after systemic administration, which emphasizes the relevance of the mPFC as a site of action of these antipsychotic drugs in offsetting the neurochemical effects of MK-801.

The Serotonin 5-HT2A Receptors Antagonist M100907 Prevents Impairment in Attentional Performance by NMDA Receptor Blockade in the Rat Prefrontal Cortex

Evidence that the prefronto-cortical glutamate NMDA system may make an important contribution to the control of attention and executive functions is provided and it is indicated that 5-HT2A receptors may serve to optimize attentional selectivity and improve some aspects of executive control.

DOI-Induced Activation of the Cortex: Dependence on 5-HT2A Heteroceptors on Thalamocortical Glutamatergic Neurons

It is found that DOI did not induce Fos in cortical 5-HT2A immunoreactive neurons but did increase expression in a band of neurons spanning superficial layer V to deep III, within the apical dendritic fields of layer V 5- HT2A-immunoreactive cells.