AMPA receptor involvement in 5-hydroxytryptamine2A receptor-mediated pre-frontal cortical excitatory synaptic currents and DOI-induced head shakes

@article{Zhang2008AMPARI,
  title={AMPA receptor involvement in 5-hydroxytryptamine2A receptor-mediated pre-frontal cortical excitatory synaptic currents and DOI-induced head shakes},
  author={Ce Zhang* and Gerard J. Marek},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2008},
  volume={32},
  pages={62-71}
}
  • Ce Zhang*G. Marek
  • Published 1 January 2008
  • Biology, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry

Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice

The robust attenuation of DOI-induced head twitches in the mGlu2 receptor KO mice appears to reflect the critical role of glutamate in ongoing regulation of 5-HT2A receptors in the prefrontal cortex.

Interactions of Hallucinogens with the Glutamatergic System: Permissive Network Effects Mediated Through Cortical Layer V Pyramidal Neurons.

  • G. Marek
  • Biology
    Current topics in behavioral neurosciences
  • 2018
The effects on 5-HT2A receptors and related GPCRs appear to play a major role in the behavioral effects of serotonergic hallucinogens, such as head twitches in rodents and higher order behaviors such as rodent lever pressing on the differential-reinforcement-of-low rate 72-s (DRL72-s) schedule.

Regulation of Cortical 5-Hydroxytryptamine 2A -Receptor Mediated Electrophysiological Responses in the Rat Following Daily Oral Lithium Administration

  • Psychology, Biology
  • 2016
While not having an effect on the concentration-response of 5-HT-induced EPSCs in the medial PFC, lithium did enhance both the onset and magnitude of desensitization for 5-hydroxytryptamine 2A (5-HT 2A) receptor trafficking lithium in the PFC.

D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT2A receptor agonist DOI

Orexin 2 Receptor Antagonists from Prefrontal Cortical Circuitry to Rodent Behavioral Screens

The treatment of mood disorders is an additional potential indica-tion for orexin receptor antagonists beyond simply improving sleep by suppressing hallucinogen-induced head twitches and producing antidepressant-like effects on the differential-reinforcement-of-low-rate 72-s (DRL72-s) schedule of reinforcement.

Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen

Chronic treatment with the mGlu2/3 agonist LY379268 would alter the behavioral response to a phenethylamine hallucinogen, 25CN-NBOH, which acts as a selective 5-HT2A agonist, and these data support the hypothesis that mGlam 2/3 receptors play a prominent role in modulating the behavior response to 5- HT2A receptor activation.

Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice

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