AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability.

@article{Vandenberghe2000AMPARC,
  title={AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability.},
  author={Wim Vandenberghe and E C Ihle and Doris K Patneau and Wim Robberecht and James R. Brorson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 19},
  pages={7158-66}
}
Spinal motoneurons are more susceptible to AMPA receptor-mediated injury than are other spinal neurons, a property that has been implicated in their selective degeneration in amyotrophic lateral sclerosis (ALS). The aim of this study was to determine whether this difference in vulnerability between motoneurons and other spinal neurons can be attributed to a difference in AMPA receptor desensitization and/or to a difference in density of functional AMPA receptors. Spinal motoneurons and dorsal… CONTINUE READING
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