AMPA-induced dark cell degeneration of cerebellar Purkinje neurons involves activation of caspases and apparent mitochondrial dysfunction.

@article{Strahlendorf2003AMPAinducedDC,
  title={AMPA-induced dark cell degeneration of cerebellar Purkinje neurons involves activation of caspases and apparent mitochondrial dysfunction.},
  author={Jean C. Strahlendorf and Cathy Box and Jennifer Attridge and Janet Diertien and Velvetlee Finckbone and W Mike Henne and Margarita S Medina and Randy C. Miles and Sowmini Oomman and M{\'a}rcia A Schneider and Hema Singh and Madhu Veliyaparambil and Howard K. Strahlendorf},
  journal={Brain research},
  year={2003},
  volume={994 2},
  pages={146-59}
}
Cerebellar Purkinje neurons (PNs) are selectively vulnerable to AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepriopionic acid)-induced delayed neurotoxicity known as dark cell degeneration (DCD) that is expressed as cytoplasmic and nuclear condensation, neuron shrinkage, and failure of physiology. The present study was initiated to determine whether AMPA-receptor-induced DCD in PNs is associated with Bax translocation to the mitochondria, cytochrome C release from the mitochondria, changes in… CONTINUE READING

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