AMPA/kainate receptor antagonist DNQX blocks the acute increase of Per2 mRNA levels in most but not all areas of the SCN.

@article{Paul2005AMPAkainateRA,
  title={AMPA/kainate receptor antagonist DNQX blocks the acute increase of Per2 mRNA levels in most but not all areas of the SCN.},
  author={Ketema N Paul and Chiaki Fukuhara and Mary C Karom and Gianluca Tosini and H Elliott Albers},
  journal={Brain research. Molecular brain research},
  year={2005},
  volume={139 1},
  pages={129-36}
}
The daily light:dark cycle synchronizes the circadian timing system by resetting the phase of the circadian pacemaker on a daily basis. Light acutely increases mRNA levels of the clock genes Per1 and Per2 in the suprachiasmatic nucleus (SCN), the site of the primary circadian pacemaker in mammals. Light is conveyed to the SCN through the retinohypothalamic tract (RHT), an efferent projection from retinal ganglion cells that releases the excitatory amino acid (EAA) neurotransmitter glutamate in… CONTINUE READING

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