AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis

@inproceedings{Bonnet2015AMPAkainateGR,
  title={AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis},
  author={Cleo S. Bonnet and Anwen Si{\^a}n Williams and Sophie J. Gilbert and Ann K Harvey and Bronwen A. J. Evans and Deborah J. Mason},
  booktitle={Annals of the rheumatic diseases},
  year={2015}
}
OBJECTIVES Synovial fluid glutamate concentrations increase in arthritis. Activation of kainate (KA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. We hypothesised that AMPA and KA GluRs are expressed in human arthritis, and that intra-articular NBQX (AMPA/KA GluR antagonist) prevents pain and pathology in antigen-induced arthritis (AIA). METHODS GluR immunohistochemistry… CONTINUE READING
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