AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma.

@article{Namiki2011AMPKK,
  title={AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma.},
  author={Takeshi Namiki and Atsushi Tanemura and Julio C. Valencia and Sergio G. Coelho and Thierry Passeron and Masakazu Kawaguchi and Wilfred D. Vieira and Masashi Ishikawa and Wataru Nishijima and Toshiyuki Izumo and Yasuhiko Kaneko and Ichiro Katayama and Yuji Yamaguchi and Lanlan Yin and Eric C. Polley and Hongfang Liu and Yutaka Kawakami and Yoshinobu Eishi and Eishi Takahashi and Hiroo Yokozeki and Vincent J. Hearing},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 16},
  pages={6597-602}
}
The identification of genes that participate in melanomagenesis should suggest strategies for developing therapeutic modalities. We used a public array comparative genomic hybridization (CGH) database and real-time quantitative PCR (qPCR) analyses to identify the AMP kinase (AMPK)-related kinase NUAK2 as a candidate gene for melanomagenesis, and we analyzed its functions in melanoma cells. Our analyses had identified a locus at 1q32 where genomic gain is strongly associated with tumor thickness… CONTINUE READING

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