AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

@article{Minokoshi2004AMPkinaseRF,
  title={AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus},
  author={Yasuhiko Minokoshi and Thierry Alquier and Noboru Furukawa and Young-Bum Kim and Anna Lee and Bingzhong Xue and James Mu and Fabienne Foufelle and Pascal Ferr{\'e} and Morris J. Birnbaum and Bettina Johanna Stuck and Barbara B. Kahn},
  journal={Nature},
  year={2004},
  volume={428},
  pages={569-574}
}
Obesity is an epidemic in Western society, and causes rapidly accelerating rates of type 2 diabetes and cardiovascular disease. The evolutionarily conserved serine/threonine kinase, AMP-activated protein kinase (AMPK), functions as a ‘fuel gauge’ to monitor cellular energy status. We investigated the potential role of AMPK in the hypothalamus in the regulation of food intake. Here we report that AMPK activity is inhibited in arcuate and paraventricular hypothalamus (PVH) by the anorexigenic… 
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Role of hypothalamic AMP-kinase in food intake regulation.
Role of hypothalamic 5′-AMP-activated protein kinase in the regulation of food intake and energy homeostasis
TLDR
Hypothalamic AMPK is an important signaling molecule that integrates nutritional and hormonal signals and modulates feeding behavior and energy metabolism, and appears to play a role in the central regulation of energy expenditure and peripheral glucose metabolism.
Hypothalamic AMPK: a canonical regulator of whole-body energy balance
AMP-activated protein kinase (AMPK) has a major role in the modulation of energy balance. AMPK is activated in conditions of low energy, increasing energy production and reducing energy consumption.…
Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
TLDR
Changes in hypothalamic AMPK activity are sufficient and necessary for hypothalamic nutrient-sensing mechanisms to alter glucose production in vivo, and molecular and pharmacological activation of hypothalamicAMPK negated the ability of hypothalamus nutrients to lower glucose production.
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
PAS Kinase Is a Nutrient and Energy Sensor in Hypothalamic Areas Required for the Normal Function of AMPK and mTOR/S6K1
TLDR
The data indicated that the PASK function could be critical for preserving the nutrient effect on AMPK and mTOR/S6K1 pathways and maintain the regulatory role of exendin-4 in food intake.
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
The evolutionarily conserved serine/threonine kinase, AMP‐activated protein kinase (AMPK), functions as a cellular fuel gauge that regulates metabolic pathways in glucose and fatty acid metabolism…
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.
TLDR
It is suggested that while AMPK plays a key role in hypothalamic function, it does not act as a general sensor and integrator of energy homeostasis in the mediobasal hypothalamus.
Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
TLDR
It is reported that α-lipoic acid (α-LA), a cofactor of mitochondrial enzymes, decreases hypothalamic AMPK activity and causes profound weight loss in rodents by reducing food intake and enhancing energy expenditure.
Measurement of AMP-activated protein kinase activity and expression in response to ghrelin.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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