AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

@article{Minokoshi2004AMPkinaseRF,
  title={AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus},
  author={Yasuhiko Minokoshi and Thierry Alquier and Noboru Furukawa and Young-Bum Kim and Anna Lee and Bingzhong Xue and James Mu and Fabienne Foufelle and Pascal Ferr{\'e} and Morris J. Birnbaum and Bettina Johanna Stuck and Barbara B. Kahn},
  journal={Nature},
  year={2004},
  volume={428},
  pages={569-574}
}
Obesity is an epidemic in Western society, and causes rapidly accelerating rates of type 2 diabetes and cardiovascular disease. The evolutionarily conserved serine/threonine kinase, AMP-activated protein kinase (AMPK), functions as a ‘fuel gauge’ to monitor cellular energy status. We investigated the potential role of AMPK in the hypothalamus in the regulation of food intake. Here we report that AMPK activity is inhibited in arcuate and paraventricular hypothalamus (PVH) by the anorexigenic… 
Role of hypothalamic AMP-kinase in food intake regulation.
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TLDR
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TLDR
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Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
TLDR
It is reported that α-lipoic acid (α-LA), a cofactor of mitochondrial enzymes, decreases hypothalamic AMPK activity and causes profound weight loss in rodents by reducing food intake and enhancing energy expenditure.
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TLDR
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