AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

@article{Minokoshi2004AMPkinaseRF,
  title={AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus},
  author={Y. Minokoshi and T. Alquier and N. Furukawa and Young-Bum Kim and A. Lee and B. Xue and J. Mu and F. Foufelle and P. Ferr{\'e} and M. Birnbaum and B. Stuck and B. Kahn},
  journal={Nature},
  year={2004},
  volume={428},
  pages={569-574}
}
Obesity is an epidemic in Western society, and causes rapidly accelerating rates of type 2 diabetes and cardiovascular disease. The evolutionarily conserved serine/threonine kinase, AMP-activated protein kinase (AMPK), functions as a ‘fuel gauge’ to monitor cellular energy status. We investigated the potential role of AMPK in the hypothalamus in the regulation of food intake. Here we report that AMPK activity is inhibited in arcuate and paraventricular hypothalamus (PVH) by the anorexigenic… Expand
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