AMP is a partial agonist at the sheep cardiac ryanodine receptor.


We have investigated the ability of AMP to modulate the native sheep cardiac ryanodine receptor (RyR) channel at various cytosolic [Ca2+]. Channels were incorporated into planar phospholipid bilayers and current fluctuations through the bilayer were monitored under voltage clamp conditions. We demonstrate that AMP only exhibits agonist activity if the… (More)


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