AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells.

@article{Takeuchi2013AMPdependentKI,
  title={AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells.},
  author={Kimio Takeuchi and Yuki Morizane and Cynthia Kamami-Levy and Jun Suzuki and Maki Kayama and Wenyi Cai and Joan W Miller and Demetrios G Vavvas},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 28},
  pages={20581-91}
}
Caveolin-1 is the primary structural component of endothelial caveolae that is essential for transcellular trafficking of albumin and is also a critical scaffolding protein that regulates the activity of signaling molecules in caveolae. Phosphorylation of caveolin-1 plays a fundamental role in the mechanism of oxidant-induced vascular hyper permeability. However, the regulatory mechanism of caveolin-1 phosphorylation remains unclear. Here we identify a previously unexpected role for AMPK in… CONTINUE READING
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