AMP deamination delays muscle acidification during heavy exercise and hypoxia.

@article{Korzeniewski2006AMPDD,
  title={AMP deamination delays muscle acidification during heavy exercise and hypoxia.},
  author={Bernard Korzeniewski},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 6},
  pages={3057-66}
}
In silico studies carried out by using a computer model of oxidative phosphorylation and anaerobic glycolysis in skeletal muscle demonstrated that deamination of AMP to IMP during heavy short term exercise and/or hypoxia lessens the acidification of myocytes. The concerted action of adenylate kinase and AMP deaminase, leading to a decrease in the total adenine nucleotide pool, constitutes an additional process consuming ADP and producing ATP. It diminishes the amount of ADP that must be… CONTINUE READING

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