AMP deamination delays muscle acidification during heavy exercise and hypoxia.

  title={AMP deamination delays muscle acidification during heavy exercise and hypoxia.},
  author={Bernard Korzeniewski},
  journal={The Journal of biological chemistry},
  volume={281 6},
In silico studies carried out by using a computer model of oxidative phosphorylation and anaerobic glycolysis in skeletal muscle demonstrated that deamination of AMP to IMP during heavy short term exercise and/or hypoxia lessens the acidification of myocytes. The concerted action of adenylate kinase and AMP deaminase, leading to a decrease in the total adenine nucleotide pool, constitutes an additional process consuming ADP and producing ATP. It diminishes the amount of ADP that must be… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Plasma ammonia concentrations and the slow component of oxygen uptake kinetics during cycle ergometry.

Journal of strength and conditioning research • 2008
View 15 Excerpts
Highly Influenced

Biomarkers of peripheral muscle fatigue during exercise

BMC musculoskeletal disorders • 2012
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…