AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.

@article{Amato2011AMPactivatedPK,
  title={AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.},
  author={Stephen M. Amato and Xiuxin Liu and Bin Zheng and Lewis C. Cantley and Pasko Raki{\'c} and Hengye Man},
  journal={Science},
  year={2011},
  volume={332 6026},
  pages={247-51}
}
Axon-dendrite polarization is crucial for neural network wiring and information processing in the brain. Polarization begins with the transformation of a single neurite into an axon and its subsequent rapid extension, which requires coordination of cellular energy status to allow for transport of building materials to support axon growth. We found that activation of the energy-sensing adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway suppressed axon initiation and… CONTINUE READING

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