AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins.

@article{Leff2003AMPactivatedPK,
  title={AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins.},
  author={Todd Leff},
  journal={Biochemical Society transactions},
  year={2003},
  volume={31 Pt 1},
  pages={224-7}
}
  • Todd Leff
  • Published 2003 in Biochemical Society transactions
One of the primary functions of AMP-activated protein kinase (AMPK) is to regulate the metabolic pathways in response to reduced cellular energy charge. Most of the known targets of the kinase are cytoplasmic enzymes involved in both catabolic and anabolic metabolism. In addition, activation of AMPK in many cells results in changes in the pattern of gene expression. Although some of these effects are undoubtedly secondary responses to modified cellular metabolism, it is possible that in… CONTINUE READING
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