AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells.

@article{Li2008AMPactivatedPK,
  title={AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells.},
  author={Xiaoxia Li and Yingying Han and Wei Pang and Chenghong Li and Xuefen Xie and John Y-J Shyy and Yi Zhu},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 10},
  pages={1789-95}
}
OBJECTIVE Endothelial progenitor cells (EPCs) can differentiate into endothelial cells (ECs) and participate in postnatal vasculogenesis, but the mechanism of EPC differentiation remains largely unknown. We investigated the role of AMP-activated protein kinase (AMPK) in EPC differentiation and functions. METHODS AND RESULTS Vascular endothelial growth factor caused the phosphorylation of AMPK, acetyl-coenzymeA (CoA) carboxylase (ACC), and eNOS in human cord blood-derived EPCs. The expression… CONTINUE READING

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The expression of EC markers , including VE - cadherin and intercellular adhesion molecule1 ( ICAM-1 ) , was also increased but blocked by Compound C , an AMPK inhibitor .
The expression of EC markers , including VE - cadherin and intercellular adhesion molecule1 ( ICAM-1 ) , was also increased but blocked by Compound C , an AMPK inhibitor .
Endothelial progenitor cells ( EPCs ) can differentiate into endothelial cells ( ECs ) and participate in postnatal vasculogenesis , but the mechanism of EPC differentiation remains largely unknown .
Endothelial progenitor cells ( EPCs ) can differentiate into endothelial cells ( ECs ) and participate in postnatal vasculogenesis , but the mechanism of EPC differentiation remains largely unknown .
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