AMP-activated protein kinase phosphorylates CtBP1 and down-regulates its activity.

  title={AMP-activated protein kinase phosphorylates CtBP1 and down-regulates its activity.},
  author={Jae-Hwan Kim and Soo-Youn Choi and Byung-Hee Kang and Seokjoon Lee and Hyung Soon Park and Gum-Yong Kang and Joo Young Bang and Eun-Jung Cho and Hong-Duk Youn},
  journal={Biochemical and biophysical research communications},
  volume={431 1},
CtBP is a transcriptional repressor which plays a significant role in the regulation of cell proliferation and tumor progression. It was reported that glucose withdrawal causes induction of Bax due to the dissociation of CtBP from the Bax promoter. However, the precise mechanism involved in the regulation of CtBP still remains unclear. In this study, we found that an activated AMP-activated protein kinase (AMPK) phosphorylates CtBP1 on Ser-158 upon metabolic stresses. Moreover, AMPK-mediated… CONTINUE READING


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