AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.

@article{Kilbride2010AMPactivatedPK,
  title={AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.},
  author={Se{\'a}n M. Kilbride and Angela M. Farrelly and Caroline K. Bonner and Manus W. Ward and Kristine C. Nyhan and Caoimh{\'i}n G. Concannon and Claes B Wollheim and Maria M. Byrne and Jochen H. M. Prehn},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 46},
  pages={36199-206}
}
Heterozygous loss-of-function mutations in the hepatocyte nuclear factor 1A (HNF1A) gene result in the pathogenesis of maturity-onset diabetes-of-the-young type 3, (HNF1A-MODY). This disorder is characterized by a primary defect in metabolism-secretion coupling and decreased beta cell mass, attributed to excessive beta cell apoptosis. Here, we investigated the link between energy stress and apoptosis activation following HNF1A inactivation. This study employed single cell fluorescent microscopy… CONTINUE READING
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AMPK Mediates Bmf Expression in Response to Energetic Stress 36206 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • R. M. Memmott, P. A. Dennis
  • NOVEMBER 12,
  • 2009
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