AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury.

@article{Stone2013AMPactivatedPK,
  title={AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury.},
  author={Joshua D. Stone and Avinash Narine and Patti R Shaver and Jonathan C. Fox and Jackson Ross Vuncannon and David A Tulis},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={304 3},
  pages={H369-81}
}
Vascular smooth muscle cell (VSMC) activation promotes a synthetic phenotype that underlies many vessel growth disorders. In this regard it has been suggested that the metabolic sensor adenosine 5'-monophosphate-activated protein kinase (AMPK) has significant antigrowth and antimetastatic properties and may serve as a viable therapeutic target. In the current study we hypothesized that AMPK reduces neointima formation following balloon injury and that this occurs through reduction in VSMC… CONTINUE READING

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