AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes.

@article{Foretz1998AMPactivatedPK,
  title={AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes.},
  author={Marc Foretz and David Carling and C{\'e}cile Guichard and Pascal Ferr{\'e} and Fabienne Foufelle},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 24},
  pages={
          14767-71
        }
}
Although it is now clearly established that a number of genes involved in glucose and lipid metabolism are up-regulated by high glucose concentrations in both liver and adipose tissue, the signaling pathway arising from glucose to the transcriptional machinery is still poorly understood. We have analyzed the regulation of fatty acid synthase gene expression by glucose in cultured rat hepatocytes. Glucose (25 mM) induces an activation of the transcription of the fatty acid synthase gene, and… CONTINUE READING

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