AMP-activated protein kinase in metabolic control and insulin signaling.

  title={AMP-activated protein kinase in metabolic control and insulin signaling.},
  author={Mhairi C. Towler and David Grahame Hardie},
  journal={Circulation research},
  volume={100 3},
The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Activation in response to increases in AMP involves phosphorylation by an upstream kinase, the tumor suppressor LKB1. In certain cells… CONTINUE READING
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