AMP-activated protein kinase as a target for preconditioning in transplantation medicine.

  title={AMP-activated protein kinase as a target for preconditioning in transplantation medicine.},
  author={Hjalmar R. Bouma and Marlies E Ketelaar and Benito Antonio Yard and Rutger J Ploeg and Robert H. Henning},
  volume={90 4},
Graft quality before transplantation is a major factor influencing chronic rejection. Organ preservation and ischemia/reperfusion play an important role in the induction of organ injury. Although both suppression of metabolism by hypothermic preservation and preconditioning before ischemia limit injury, understanding the biochemical signaling pathways will allow us to optimize graft preservation further. Adenosine monophosphate-activated protein kinase (AMPK) is an important enzyme sensing… CONTINUE READING


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Adenosine monophosphate-activated protein kinase (AMPK) as a new target for antidiabetic drugs: A review on metabolic, pharmacological and chemical considerations

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