AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma.

@article{Kim2010AMPactivatedPK,
  title={AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma.},
  author={Min-Jung Kim and In-Ja Park and Hee Tae Yun and Insug Kang and Wonchae Choe and Sung-Soo Kim and Joohun Ha},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 19},
  pages={14617-27}
}
Mitogen-activated protein kinase (MAPK) pathways are involved in the regulation of cellular responses, including cell proliferation, differentiation, cell growth, and apoptosis. Because these responses are tightly related to cellular energy level, AMP-activated protein kinase (AMPK), which plays an essential role in energy homeostasis, has emerged as another key regulator. In the present study, we demonstrate a novel signal network between AMPK and MAPK in HCT116 human colon carcinoma. Glucose… CONTINUE READING
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Regulation of ERK by AMPK

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