AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.

@article{Krawiec2007AMPactivatedPK,
  title={AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.},
  author={Brian J. Krawiec and Gerald A J Nystrom and R. Frost and Leonard S. Jefferson and Charles H Lang},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 6},
  pages={E1555-67}
}
The hypothesis of the present study was that exposure of differentiated muscle cells to agonists of the AMP-activated protein kinase (AMPK) would increase the mRNA content of the muscle-specific ubiquitin ligases muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1). C(2)C(12) cells were incubated with incremental doses of 5-aminoimidazol-4-carboximide ribonucleoside (AICAR) or metformin for 24 h. Both MAFbx and MuRF1 mRNA increased dose dependently in response to these AMPK activators… CONTINUE READING

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