AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats.

@article{Ford2012AMPactivatedPK,
  title={AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats.},
  author={Rebecca J. Ford and Susan R Teschke and Elizabeth B. Reid and Kristina K. Durham and Jeffrey T E Kroetsch and James W. E. Rush},
  journal={Journal of hypertension},
  year={2012},
  volume={30 4},
  pages={725-33}
}
OBJECTIVES AMP-activated protein kinase (AMPK) activity may alter blood pressure by directly influencing vascular tone. The purpose of this study is to examine if these effects occur acutely in a model of hypertension. METHODS AND RESULTS Using distinct groups of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) we compare baseline aortic and mesenteric artery AMPK activation (by immunoblotting), hemodynamic (blood pressure and heart rate via carotid catheter) and biochemical… CONTINUE READING
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