AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo.

@article{Iglesias2004AMPactivatedPK,
  title={AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo.},
  author={Miguel Angel Iglesias and Stuart M Furler and Gregory James Cooney and Edward W. Kraegen and Ji-Ming Ye},
  journal={Diabetes},
  year={2004},
  volume={53 7},
  pages={1649-54}
}
Insulin-stimulated glucose uptake is increased in white but not red muscle of insulin-resistant high-fat-fed (HF) rats after administration of the AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR). To investigate whether a lesser AICAR effect on glucose uptake in red muscle was offset by a greater effect on fatty acid (FA) uptake, we examined acute effects of AICAR on muscle glucose and FA fluxes in HF rats. HF rats received AICAR (250… CONTINUE READING
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