AMP-activated protein kinase--an archetypal protein kinase cascade?

  title={AMP-activated protein kinase--an archetypal protein kinase cascade?},
  author={David Grahame Hardie and R W Mackintosh},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={14 10},
Mammalian AMP-activated protein kinase is the central component of a protein kinase cascade which inactivates three key enzymes involved in the synthesis or release of free fatty acids and cholesterol inside the cell. The kinase cascade is activated by elevation of AMP, and perhaps also by fatty acid and cholesterol metabolites. The system may fulfil a protective function, preventing damage caused by depletion of ATP or excessive intracellular release of free lipids, a type of stress response… CONTINUE READING


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