AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation.

Abstract

Monocyte-to-macrophage differentiation, which can be initiated by physiological or atherogenic factors, is a pivotal process in atherogenesis, a disorder in which monocytes adhere to endothelial cells and subsequently migrate into the subendothelial spaces, where they differentiate into macrophages and macrophage-derived foam cells and cause atherosclerotic… (More)
DOI: 10.1074/jbc.M117.779447

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